{"id":70860,"date":"2016-03-30T10:29:42","date_gmt":"2016-03-30T10:29:42","guid":{"rendered":"http:\/\/fintech.commercegurus.com\/?page_id=70857"},"modified":"2021-10-24T21:59:06","modified_gmt":"2021-10-24T21:59:06","slug":"harnessing-human-immunity","status":"publish","type":"page","link":"https:\/\/papivax.com\/zh\/hpv\/harnessing-human-immunity\/","title":{"rendered":"\u5229\u7528\u4eba\u985e\u5c0d HPV \u7684\u514d\u75ab\u529b"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p><\/p>\n<p>[vc_row type=&#8221;container&#8221; padding_top=&#8221;&#8221; padding_bottom=&#8221;&#8221; css=&#8221;.vc_custom_1458057033586{margin-bottom: 0px !important;}&#8221;][vc_column][vc_column_text]\u7f8e\u570b FDA \u5df2\u6838\u51c6\u6578\u7a2e\u9810\u9632\u6027 HPV \u75ab\u82d7\uff1b\u9996\u5148\u662f 2006 \u5e74\u9ed8\u6c99\u6771\u85e5\u5ee0\uff08Merck\uff09\u7684\u5609\u559c\u75ab\u82d7\uff08Gardasil<sup>\u00a9<\/sup>\uff0c\u91dd\u5c0d HPV6\u300111\u300116 \u548c 18 \u56db\u578b\uff09\u4ee5\u53ca 2009 \u5e74\u845b\u862d\u7d20\u53f2\u514b\u85e5\u5ee0\uff08GlaxcoSmithKline\uff0c\u7c21\u7a31 GSK\uff09\u7684 Cervarix<sup>\u00a9<\/sup>\uff08\u5c0d\u6297 HPV16 \u548c 18 \u5169\u578b\uff09\uff0c\u4f9b\u5152\u7ae5\u8207\u9752\u5c11\u5e74\u63a5\u7a2e\u4ee5\u9810\u9632 hrHPV \u76f8\u95dc\u7684\u5bae\u9838\u764c\u3002Gardasil<sup>\u00a9<\/sup> \u5f8c\u4f86\u66f4\u65b0\u70ba Gardasil 9<sup>\u00a9<\/sup>\uff0c\u4e26\u65bc 2014 \u5e74\u7372\u51c6\u4f9b 26 \u6b72\u548c\u4ee5\u4e0b\u7684\u5e74\u8f15\u6210\u4eba\u63a5\u7a2e\u30022018 \u5e74 Gardasil 9<sup>\u00a9<\/sup> \u9069\u7528\u65cf\u7fa4\u64f4\u5c55\u5230 45 \u6b72\u548c\u4ee5\u4e0b\u7684\u6210\u4eba\u63a5\u7a2e\uff0c\u4ee5\u9810\u9632 HPV \u76f8\u95dc\u4e4b\u5bae\u9838\u764c\u3001\u5916\u9670\u764c\u3001\u9670\u9053\u764c\u3001\u809b\u9580\u764c\u548c\u53e3\u54bd\u764c\/\u982d\u9838\u764c\u3002\u9019\u4e9b\u75ab\u82d7\u85c9\u7531\u5728\u4eba\u9ad4\u5faa\u74b0\u8207\u5206\u6ccc\u6db2\u4e2d\u7522\u751f\u7684\u5177 HPV \u7279\u7570\u6027\u7684\u4e2d\u548c\u6297\u9ad4\uff0c\u4f86<strong><u>\u9810\u9632<\/u><\/strong>\u65b0 HPV \u611f\u67d3\uff1b\u5230\u76ee\u524d\u5b83\u5011\u7684\u5b89\u5168\u6027\u8207\u6548\u679c\u5747\u5df2\u7372\u8b49\u5be6\u3002\u4e00\u65e6\u4eba\u9ad4\u7d30\u80de\u53d7\u5230 HPV \u611f\u67d3\uff0c\u5c0d HPV \u6709\u7279\u7570\u6027\u7684\u7d30\u80de\u6bd2\u6027 T \u6dcb\u5df4\u7d30\u80de\uff08cytotoxic T lymphocytes\uff09\u5728\u6a39\u7a81\u72c0\u7d30\u80de\uff08dendritic cells\uff09\u7684\u5e6b\u52a9\u4e0b\uff0c\u80fd\u5075\u6e2c\u5230\u4e26\u6d88\u6ec5\u9019\u4e9b\u53d7\u611f\u67d3\u7684\u7d30\u80de\u3002\u7531\u65bc\u6b64\u985e\u9810\u9632\u6027\u75ab\u82d7\u7121\u6cd5\u7528\u4f86<strong><u>\u6cbb\u7642<\/u><\/strong>\u65e2\u5b58\u7684 HPV \u611f\u67d3\uff0c\u5168\u7403\u7684 HPV \u611f\u67d3\u7387\u4f9d\u7136\u5c45\u9ad8\u4e0d\u4e0b\uff0c\u5176\u539f\u56e0\u5982\u4e0b\uff1a\u9810\u9632\u6027 HPV \u75ab\u82d7\u8fd1\u5e74\u65b9\u624d\u554f\u4e16\uff0c\u8a31\u591a\u570b\u5bb6\u5c1a\u672a\u63a8\u51fa\u6709\u6548\u7684\u5168\u570b\u75ab\u82d7\u63a5\u7a2e\u8a08\u756b\uff1b\u81f3\u65bc\u5728\u5df2\u63a8\u884c\u75ab\u82d7\u63a5\u7a2e\u7684\u570b\u5bb6\uff0c\u8a31\u591a\u6c11\u773e\u4ecd\u9078\u64c7\u4e0d\u63a5\u7a2e\u75ab\u82d7\u3002\u96a8\u8457\u793e\u7d93\u5730\u4f4d\u3001\u5730\u7406\u689d\u4ef6\u3001\u6587\u5316\u80cc\u666f\u7684\u5dee\u7570\u548c\u5176\u4ed6\u56e0\u7d20\uff0c\u5404\u570b\u9810\u9632\u6027 HPV \u75ab\u82d7\u63a5\u7a2e\u7387\u5dee\u7570\u9817\u5927\u3002\u4e00\u822c\u800c\u8a00\uff0c\u4f4e\u958b\u767c\u3001\u570b\u6c11\u6536\u5165\u4f4e\u7684\u570b\u5bb6\u7684\u75ab\u82d7\u63a5\u7a2e\u7387\u4f4e\u65bc\u5df2\u958b\u767c\u570b\u5bb6\u3002\u7f8e\u570b\u8207\u53f0\u7063\u7684\u75ab\u82d7\u63a5\u7a2e\u7387\u90fd\u5927\u7d04\u5728 60% \u5de6\u53f3\uff0c\u4e14\u6578\u5b57\u4ecd\u6301\u7e8c\u4e0a\u5347\u3002\u65e5\u672c\u7684\u72c0\u6cc1\u76f8\u7576\u7368\u7279\uff0c\u53ef\u5f70\u986f\u516c\u885b\u754c\u63a8\u5ee3 HPV \u75ab\u82d7\u63a5\u7a2e\u4e4b\u96e3\u8655\u3002\u81ea\u5f9e Cervarix<sup>\u00a9<\/sup> \u65bc 2009 \u5e74 10 \u6708\u5728\u65e5\u672c\u7372\u5f97\u6838\u51c6\u5f8c\uff0c\u65e5\u672c\u5973\u6027\u7684\u9810\u9632\u6027 HPV \u75ab\u82d7\u63a5\u7a2e\u7387\u8fc5\u901f\u5728 3-4 \u5e74\u9593\u589e\u52a0\u81f3\u8d85\u904e 70%\u3002\u65e5\u672c\u65bc 2013 \u5e74\u5728\u653f\u5e9c\u5efa\u8b70\u4e0b\u958b\u59cb\u63a8\u884c\u5168\u570b\u6027\u7684\u75ab\u82d7\u63a5\u7a2e\u8a08\u756b\uff1b\u6c92\u60f3\u5230\u8a08\u756b\u958b\u59cb\u624d\u4e8c\u500b\u6708\uff0c\u7531\u65bc\u5a92\u9ad4\u5927\u5e45\u5831\u5c0e\u5c0d\u75ab\u82d7\u63a5\u7a2e\u7522\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u7f55\u898b\u75c5\u4f8b\uff0c\u9020\u6210\u8f3f\u8ad6\u8fc5\u901f\u8f49\u5411\uff0c\u6c11\u773e\u6297\u62d2\u63a5\u7a2e\u9810\u9632\u6027 HPV \u75ab\u82d7\uff0c\u5c0e\u81f4\u65e5\u672c\u65bc 2013 \u5e74 6 \u6708\u7121\u9650\u671f\u66ab\u505c\u653f\u5e9c\u5c0d\u63a5\u7a2e\u9810\u9632\u6027 HPV \u75ab\u82d7\u7684\u5efa\u8b70\uff1b\u4e4b\u5f8c\u5e74\u8f15\u65e5\u672c\u5973\u6027\u7684\u75ab\u82d7\u63a5\u7a2e\u7387\u5728\u4e09\u5e74\u5167\u5f9e 74% \u8dcc\u81f3 0.7%\u3002\u5728\u6b64\u540c\u6642\uff0c\u65e5\u672c\u7684\u5bae\u9838\u764c\u6b7b\u4ea1\u7387\u5f9e 1995 \u5e74\u7684 3.6% \u5347\u9ad8\u81f3 2018 \u5e74\u7684 4.5% <a href=\"https:\/\/ganjoho.jp\/reg_stat\/statistics\/dl\/index.html\">ref<\/a>.<\/p>\n<p>\u56e0\u70ba\u9810\u9632\u6027 HPV \u75ab\u82d7\u7684\u63a5\u7a2e\u4e0d\u6613\u666e\u53ca\uff0c\u5168\u570b\u6027\u5bae\u9838\u7be9\u6aa2\u8a08\u756b\uff08\u62b9\u7247\u7d30\u80de\u5b78\u548c HPV \u6aa2\u6e2c\uff09\u4ecd\u7136\u7e7c\u7e8c\u9032\u884c\uff0c\u800c\u8207 HPV \u6709\u95dc\u7684\u764c\u75c7\u7387\u4e5f\u6301\u7e8c\u6500\u5347\uff0c\u5c0d\u6cbb\u7642\u6027 HPV \u75ab\u82d7\u7684\u9700\u6c42\u4e5f\u65e5\u6f38\u5347\u9ad8\u3002\u5982\u679c PBI \u91dd\u5c0d\u9ad8\u5371\u96aa\u578b\u4eba\u985e\u4e73\u7a81\u7624\u75c5\u6bd2\uff08hrHPV\uff09\u7684\u6cbb\u7642\u6027\u75ab\u82d7\u80fd\u5920\u65e2\u5b89\u5168\u3001\u53c8\u6709\u6548\u7684\u6cbb\u7642 hrHPV \u5bae\u9838\u611f\u67d3\uff0c\u9032\u800c\u907f\u514d\u5bae\u9838\u764c\u524d\u75c5\u8b8a\u7684\u767c\u751f\uff0c\u8abf\u67e5\u986f\u793a\u75c5\u4eba\u5c07\u5f88\u9858\u610f\u63a5\u53d7\u9019\u7a2e\u65b0\u85e5\u6cbb\u7642\u3002IQVIA\uff08\u827e\u6606\u7def\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff09\u65bc 2020 \u5e74\u5728\u53f0\u7063\u8a2a\u554f\u95dc\u9375\u610f\u898b\u9818\u8896\uff08\u8cc7\u6df1\u5a66\u79d1\u91ab\u5e2b\uff09\u7684\u7d50\u679c\u986f\u793a\uff0c\u5982\u679c\u5e02\u5834\u4e0a\u6709\u65e2\u5b89\u5168\u3001\u53c8\u6709\u6548\u7684\u65b0\u85e5\u80fd\u5920\u6cbb\u7642\u6301\u7e8c\u6027 hrHPV \u5bae\u9838\u611f\u67d3\uff0c\u6709 75% \u7684\u53d7\u8a2a\u91ab\u5e2b\u9858\u610f\u958b\u8655\u65b9\u6cbb\u7642\u7d66\u4ed6\u7684\u75c5\u4eba\u3002\u6211\u5011\u8981\u5f37\u8abf\uff0c\u5982\u6b64\u65e9\u671f\u4e14\u6709\u6548\u7684\u4ecb\u5165\u6cbb\u7642\u6301\u7e8c\u6027 hrHPV \u5bae\u9838\u611f\u67d3\u5c07\u5728\u516c\u885b\u5c64\u9762\u5e36\u4f86\u6975\u5927\u7684\u6b63\u9762\u5f71\u97ff\uff0c\u56e0\u70ba\u5982\u6b64\u4e00\u4f86\u53ef\u4ee5\u964d\u4f4e HPV \u6240\u5c0e\u81f4\u6240\u6709\u764c\u75c7\u7684\u76f8\u95dc\u91ab\u7642\u6210\u672c <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33888488\/\">ref<\/a>.<\/p>\n<p>\u75ab\u82d7\u9810\u9632\u548c\u6cbb\u7642\u5bae\u9838\u764c\u7684\u6a5f\u6703\u9ede<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-72315\" src=\"https:\/\/papivax.com\/wp-content\/uploads\/2021\/10\/Screen-Shot-2021-10-24-at-2.58.05-PM.png\" alt=\"\" width=\"2200\" height=\"740\" srcset=\"https:\/\/papivax.com\/wp-content\/uploads\/2021\/10\/Screen-Shot-2021-10-24-at-2.58.05-PM.png 2200w, https:\/\/papivax.com\/wp-content\/uploads\/2021\/10\/Screen-Shot-2021-10-24-at-2.58.05-PM-300x101.png 300w, https:\/\/papivax.com\/wp-content\/uploads\/2021\/10\/Screen-Shot-2021-10-24-at-2.58.05-PM-1024x344.png 1024w, https:\/\/papivax.com\/wp-content\/uploads\/2021\/10\/Screen-Shot-2021-10-24-at-2.58.05-PM-768x258.png 768w, https:\/\/papivax.com\/wp-content\/uploads\/2021\/10\/Screen-Shot-2021-10-24-at-2.58.05-PM-1536x517.png 1536w, https:\/\/papivax.com\/wp-content\/uploads\/2021\/10\/Screen-Shot-2021-10-24-at-2.58.05-PM-2048x689.png 2048w\" sizes=\"auto, (max-width: 2200px) 100vw, 2200px\" \/>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<p><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;container&#8221; padding_top=&#038;#8221 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