{"id":71580,"date":"2021-07-06T10:40:46","date_gmt":"2021-07-06T10:40:46","guid":{"rendered":"https:\/\/papivax.com\/?page_id=71580"},"modified":"2026-06-10T20:34:02","modified_gmt":"2026-06-10T20:34:02","slug":"pbi-medicines-pipeline","status":"publish","type":"page","link":"https:\/\/papivax.com\/zh\/our-technologies\/pbi-medicines-pipeline\/","title":{"rendered":"\u7522\u54c1\u958b\u767c\u6642\u7a0b\u8868"},"content":{"rendered":"

[vc_row type=”container”][vc_column][vc_single_image image=”72516″ img_size=”full” alignment=”center” css=””][vc_column_text css=””]<\/p>\n

(1) PVX-4<\/strong><\/h4>\n

PVX-4 \u70ba\u4e00\u6b3e\u5275\u65b0\u7684 DNA \u6cbb\u7642\u6027\u75ab\u82d7\uff0c\u5176\u6838\u5fc3\u8a2d\u8a08\u878d\u5408\u4e86 HPV 16 \u7684 E6\u3001E7\u3001L2 \u57fa\u56e0\u8207\u9223\u7db2\u86cb\u767d\uff08Calreticulin, CRT\uff09\uff0c\u4e26\u900f\u904e\u5c08\u5229 TriGrid\u2122 \u96fb\u7a7f\u5b54\u7cfb\u7d71\u9032\u884c\u9ad8\u6548\u7684\u7d30\u80de\u5167\u905e\u9001\u3002<\/p>\n

\u5728\u7f8e\u570b\u7d04\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b78\uff08JHU\uff09\u53ca\u963f\u62c9\u5df4\u99ac\u5927\u5b78\u4f2f\u660e\u7ff0\u5206\u6821\uff08UAB\uff09\u6240\u57f7\u884c\u7684\u7b2c\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0cPVX-4 \u4e0d\u50c5\u5c55\u73fe\u51fa\u512a\u7570\u7684\u5b89\u5168\u6027\uff0c\u66f4\u7e73\u51fa\u4ee4\u4eba\u77da\u76ee\u7684\u7642\u6548\u6578\u64da\uff1a\u8fd1\u516b\u6210\u60a3\u8005\u9ad4\u5167\u7684 HPV 16 \u578b\u75c5\u6bd2\u906d\u5230\u5b8c\u5168\u6e05\u9664\uff0c\u4e14\u5b50\u5bae\u9838\u4e0a\u76ae\u9ad8\u5ea6\u764c\u524d\u75c5\u8b8a\u7372\u5f97\u5b8c\u5168\u6cbb\u7652\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u6b64\u7642\u6cd5\u5728\u514d\u75ab\u7cfb\u7d71\u8f03\u5f31\u7684\u611b\u6ecb\u75c5\uff08HIV\uff09\u611f\u67d3\u65cf\u7fa4\u4e2d\uff0c\u4f9d\u7136\u767c\u63ee\u540c\u7b49\u7642\u6548\uff0c\u5145\u5206\u5370\u8b49\u4e86 PVX-4 \u5177\u5099\u5353\u8d8a\u4e14\u5f37\u6548\u7684\u514d\u75ab\u6d3b\u5316\u80fd\u529b\u3002<\/p>\n

\u5960\u57fa\u65bc\u4e00\u671f\u81e8\u5e8a\u7684\u4eae\u773c\u6210\u679c\uff0c\u6211\u5011\u6b63\u7a4d\u6975\u64f4\u5c55\u4e8c\u671f\u81e8\u5e8a\u4f48\u5c40\uff0c\u4ee5\u9032\u4e00\u6b65\u9a57\u8b49\u5176\u300c\u75c5\u6bd2\u6e05\u9664\u300d\u8207\u300c\u75c5\u7076\u6d88\u9000\u300d\u4e4b\u96d9\u91cd\u7642\u6548\u3002\u76ee\u524d\u96d9\u8ecc\u63a8\u9032\u7684\u8a08\u756b\uff0c\u5305\u542b\u91dd\u5c0d\u5b50\u5bae\u9838\u4e0a\u76ae\u9ad8\u5ea6\u764c\u524d\u75c5\u8b8a\u7684\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u4ee5\u53ca\u7531\u4f73\u63da\u751f\u6280\u8207\u53f0\u7063\u5a66\u764c\u7814\u7a76\u5718\u9ad4\u651c\u624b\u5408\u4f5c\u7684 HPV 16 \u6301\u7e8c\u6027\u611f\u67d3\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u8fc4\u4eca\uff0c\u5b50\u5bae\u9838\u4e0a\u76ae\u9ad8\u5ea6\u764c\u524d\u75c5\u8b8a\u5c08\u6848\u5df2\u6b63\u5f0f\u53d6\u5f97\u7f8e\u570b FDA \u53ca\u53f0\u7063 TFDA \u7684\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\u6838\u51c6\uff0c\u4e26\u5df2\u5168\u9762\u555f<\/b>\u52d5\u53d7\u8a66\u8005\u6536\u6848\u4f5c\u696d\u3002<\/p>\n

(2) PVX-7<\/strong><\/h4>\n

PVX-7\u662f\u7531HPV16\u300118\u75c5\u6bd2\u7684E6\u3001E7\u3001L2\u57fa\u56e0\u8207\u71b1\u4f11\u514b\u86cb\u767d (HSP70) \u5206\u5b50\u7d44\u6210\u7684DNA\u75ab\u82d7\uff0c\u63a1\u7528\u4e00\u822c\u808c\u8089\u6ce8\u5c04\uff0c\u524d\u5169\u5291\u70baDNA\u75ab\u82d7\uff0c\u4e26\u4f7f\u7528\u91cd\u7d44\u75d8\u75c5\u6bd2\u86cb\u767d(TA-HPV) \u505a\u70ba\u7b2c\u4e09\u5291\u7684\u52a0\u514d\u75ab\u82d7\uff0c\u7528\u65bc\u6cbb\u7642\u56e0\u611f\u67d3HPV\u5f15\u8d77\u4e4b\u665a\u671f\u5b50\u5bae\u9838\u764c\u3001\u53e3\u54bd\u764c\u3002\u4f73\u63da\u76ee\u524d\u8207\u7f8e\u570b\u8303\u5fb7\u5821\u5927\u5b78\u91ab\u5b78\u4e2d\u5fc3 (VUMC) \u5408\u4f5c\u9032\u884c\u4ee5PVX-7\u7d50\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u6cbb\u7642\u665a\u671f\u53e3\u54bd\u764c\u7684\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57 (NCT05799144)\uff0c\u53e6\u5916PVX-7\u7d50\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u7642\u6cd5\uff0c\u7528\u65bc\u6cbb\u7642\u5b50\u5bae\u9838\u764c\u7684\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u5df2\u7372\u5f97\u7f8e\u570bFDA\u6838\u51c6 (IND 27465)\u3002<\/p>\n

(3) PVX-8<\/strong><\/h4>\n

\u91ab\u754c\u5c0d\u65bc\u6301\u7e8c\u6027 HPV16 \u5bae\u9838\u611f\u67d3\u4e26\u5b58\u764c\u524d\u75c5\u8b8a(ASC-US\/ASC-H\/LSIL\/CIN1)\u7684\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u7121\u6709\u6548\u7684\u7642\u6cd5\u3002\u9019\u4e9b\u60a3\u8005\u53ea\u80fd\u300c\u63d0\u5fc3\u540a\u81bd\u7684\u7b49\u5f85\u300d\uff0c\u4e26\u85c9\u7531\u6bcf 6-12 \u500b\u6708\u4e00\u6b21\u7684\u8907\u8a3a\uff0c\u53cd\u8986\u9032\u884c\u5b50\u5bae\u9838\u62b9\u7247\u6aa2\u67e5\u548c DNA \u6aa2\u6e2c\u4f86\u770b\u75c5\u60c5\u662f\u5426\u597d\u8f49\uff0c\u6216\u662f\u60e1\u5316\u6210\u9ad8\u7d1a\u5225\u764c\u524d\u75c5\u8b8a\u6216\u4fb5\u5165\u764c\u3002\u9019\u7121\u7591\u6703\u8b93\u60a3\u8005\u98fd\u53d7\u8eab\u5fc3\u7126\u616e\u53ca\u7f9e\u6127\u611f\u7684\u714e\u71ac\u3002<\/p>\n

PVX-8 \u662f\u7531HPV16\u300118\u578b\u75c5\u6bd2\u7684E6\u3001E7\u3001L2\u57fa\u56e0\u8207\u71b1\u4f11\u514b\u86cb\u767d (HSP) \u5206\u5b50\u7d44\u6210\u7684DNA\u75ab\u82d7\uff0c\u900f\u904eTriGrid\u7cfb\u7d71\u9032\u884c\u7d66\u85e5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642HPV16\u300118\u578b\u75c5\u6bd2\u7684\u6301\u7e8c\u6027\u611f\u67d3\u3002\u76ee\u524d\u85e5\u54c1\u53ca\u5b89\u6170\u5291\u5747\u4ee5\u751f\u7522\u5b8c\u7562\uff0c\u65bc2026\u5e74\u958b\u5c55PVX-8\u7684\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n

(4) RAS<\/strong><\/h4>\n

\u7531\u65bc\u9ad8\u9054 80-95% \u7684\u80f0\u81df\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\u7686\u5e36\u6709\u7279\u5b9a\u4e4b KRAS \u7a81\u8b8a\uff08\u5982 G12D\u3001G12V \u7b49\uff09\uff0c\u4f73\u63da\u4ee5\u6b64\u5171\u6709\u6297\u539f\u70ba\u9996\u9078\u9776\u9ede\uff0c\u8a2d\u8a08\u51fa\u80fd\u91dd\u5c0d RAS \u7a81\u8b8a\u7522\u751f\u5f37\u6548\u4e14\u7279\u7570\u6027\u4e4b\u6bd2\u6bba\u578b T \u7d30\u80de\uff08CD8+ T cell\uff09\u514d\u75ab\u53cd\u61c9\u7684\u6cbb\u7642\u6027 DNA \u75ab\u82d7\uff0c\u4e26\u5df2\u5728\u4eba\u6e90\u5316\u5c0f\u9f20\u6a21\u578b\u4e2d\u8b49\u5be6\u5177\u5099\u986f\u8457\u6291\u5236 RAS \u7a81\u8b8a\u816b\u7624\u751f\u9577\u7684\u6297\u816b\u7624\u7642\u6548\u3002<\/p>\n

\u5728\u958b\u767c\u7b56\u7565\u4e0a\uff0c\u4f73\u63da\u63a1\u53d6\u52a0\u901f\u958b\u767c\u8def\u5f91\uff1a\u7531\u65bc\u8a72 DNA \u8f09\u9ad4\u8207 CRT \u6280\u8853\u5728\u5176\u4ed6\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5df2\u7372\u8b49\u5be6\u5177\u5099\u826f\u597d\u5b89\u5168\u6027\uff0c\u516c\u53f8\u9810\u8a08\u5411 FDA \u722d\u53d6\u514d\u9664\u81e8\u5e8a\u524d\u85e5\u7269\u6bd2\u7406\u6e2c\u8a66\uff1b\u4e0b\u4e00\u6b65\u5c07\u900f\u904e\u7814\u7a76\u8005\u767c\u8d77\u4e4b\u81e8\u5e8a\u8a66\u9a57\uff08IIT\uff09\u63a8\u9032\u5c08\u6848\uff0c\u4ee5\u7c21\u5316\u884c\u653f\u6d41\u7a0b\u4e26\u964d\u4f4e\u958b\u767c\u98a8\u96aa\uff0c\u76ee\u6a19\u5728\u52a0\u901f\u81e8\u5e8a\u4e00\u671f\u8a66\u9a57\u5f8c\u9032\u884c\u570b\u969b\u65e9\u671f\u6388\u6b0a\u3002<\/p>\n

(5) <\/b>\u500b\u4eba\u5316\u7cbe\u6e96\u6cbb\u7642<\/b><\/h4>\n

\u4f73\u63da\u751f\u6280\u5c07\u5176\u5169\u5927\u6838\u5fc3\u6280\u8853-CRT DNA \u6838\u9178\u8f09\u9ad4\u6280\u8853\u8207 TriGrid \u81ea\u52d5\u5316\u96fb\u7a7f\u5b54\u905e\u9001\u5e73\u53f0\uff0c\u9032\u4e00\u6b65\u5ef6\u4f38\u61c9\u7528\u81f3\u300c\u7cbe\u6e96\u91ab\u7642\u300d\u7684\u6700\u9ad8\u6bbf\u5802\uff1a\u900f\u904e\u63a1\u96c6\u665a\u671f\u764c\u75c7\u60a3\u8005\u7684\u816b\u7624\u7d44\u7e54\u8207\u8840\u6db2\u9032\u884c\u6b21\u4e16\u4ee3\u5b9a\u5e8f\u8207 MHC \u57fa\u56e0\u5206\u578b\uff0c\u4e26\u5229\u7528\u6578\u64da\u5eab\u9810\u6e2c\u51fa\u6700\u5177\u514d\u75ab\u6fc0\u6d3b\u6f5b\u529b\u7684\u7a81\u8b8a\u5e8f\u5217\uff0c\u85c9\u6b64\u70ba\u6bcf\u4f4d\u60a3\u8005\u91cf\u8eab\u6253\u9020\u5c08\u5c6c\u7684\u6cbb\u7642\u8def\u5f91\u3002<\/p>\n

\u6b64\u5916\uff0c\u4f73\u63da\u5728\u88fd\u9020\u4f9b\u61c9\u93c8\u4e0a\u5df2\u5efa\u7acb\u5f37\u5927\u512a\u52e2\uff0c\u5176 GMP \u88fd\u9020\u5408\u4f5c\u5925\u4f34 \u5177\u5099\u5c08\u5c6c\u7684\u6162\u75c5\u6bd2\u8f09\u9ad4\u8a2d\u8a08\u80fd\u529b\u8207\u8c50\u5bcc\u7684 FDA \u67e5\u5ee0\u7d93\u9a57\uff0c\u80fd\u914d\u5408\u500b\u4eba\u5316\u75ab\u82d7\u5f48\u6027\u3001\u5c0f\u6279\u91cf\u7684\u751f\u7522\u9700\u6c42\uff0c\u5728\u5927\u7d04 1-3 \u500b\u6708\u5167\u5feb\u901f\u5ba2\u88fd\u5316\u751f\u7522\u51fa\u500b\u4eba\u5316\u75ab\u82d7 DNA\u3002\u9019\u9805\u6280\u8853\u7a81\u7834\u4e0d\u50c5\u7a81\u7834\u4e86\u50b3\u7d71\u7d30\u80de\u6cbb\u7642\u7684\u9ad8\u6210\u672c\u8207\u8017\u6642\u74f6\u9838\uff0c\u66f4\u8b93\u4f73\u63da\u5f97\u4ee5\u7784\u6e96\u81f3 2035 \u5e74\u5168\u7403\u5c07\u7a81\u7834 120 \u5104\u7f8e\u5143\u7684\u500b\u4eba\u5316\u764c\u75c7\u75ab\u82d7\u5e02\u5834\u3002[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

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