{"id":71580,"date":"2021-07-06T10:40:46","date_gmt":"2021-07-06T10:40:46","guid":{"rendered":"https:\/\/papivax.com\/?page_id=71580"},"modified":"2024-03-30T02:11:18","modified_gmt":"2024-03-30T02:11:18","slug":"pbi-medicines-pipeline","status":"publish","type":"page","link":"https:\/\/papivax.com\/zh\/our-technologies\/pbi-medicines-pipeline\/","title":{"rendered":"\u7522\u54c1\u958b\u767c\u6642\u7a0b\u8868"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row type=&#8221;container&#8221;][vc_column][vc_single_image image=&#8221;72459&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][vc_column_text]<\/p>\n<h4><strong>(1) PVX-4<\/strong><\/h4>\n<p>PVX-4\u662f\u7531HPV 16\u7684E6, E7\u548cL2\u57fa\u56e0\u8207\u9223\u7db2\u86cb\u767d(CRT)\u5206\u5b50\u7d44\u6210\u7684DNA\u75ab\u82d7\uff0c\u4e26\u7d50\u5408TriGrid 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\u5408\u4f5c\u9032\u884c\u4ee5PVX-7\u7d50\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u6cbb\u7642\u665a\u671f\u53e3\u54bd\u764c\u7684\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57 (NCT05799144)\uff0c\u53e6\u5916PVX-7\u7d50\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u7642\u6cd5\uff0c\u7528\u65bc\u6cbb\u7642\u5b50\u5bae\u9838\u764c\u7684\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u5df2\u7372\u5f97\u7f8e\u570bFDA\u6838\u51c6 (IND 27465)\uff0c\u9810\u8a08\u5c07\u5728\u7372\u5f97NIH\u8db3\u5920\u8cc7\u91d1\u5f8c\u65bc\u555f\u52d5\u3002<\/p>\n<h4><strong>(3) PVX-8<\/strong><\/h4>\n<p>\u91ab\u754c\u5c0d\u65bc\u6301\u7e8c\u6027 HPV16 \u5bae\u9838\u611f\u67d3\u4e26\u5b58\u764c\u524d\u75c5\u8b8a(ASC-US\/ASC-H\/LSIL\/CIN1)\u7684\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u7121\u6709\u6548\u7684\u7642\u6cd5\u3002\u9019\u4e9b\u60a3\u8005\u53ea\u80fd\u300c\u63d0\u5fc3\u540a\u81bd\u7684\u7b49\u5f85\u300d\uff0c\u4e26\u85c9\u7531\u6bcf 6-12 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\u5206\u5b50\u7d44\u6210\u7684DNA\u75ab\u82d7\uff0c\u900f\u904e\u7121\u91dd\u6ce8\u5c04\u6216\u662fTriGrid\u7cfb\u7d71\u9032\u884c\u7d66\u85e5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642HPV16\u300118\u578b\u75c5\u6bd2\u7684\u6301\u7e8c\u6027\u611f\u67d3\u3002<\/p>\n<p>PVX-8\u524d\u4e00\u4ee3\u7684\u5019\u9078\u75ab\u82d7\u662fPVX2\uff0cPVX2\u91dd\u5c0d\u7684\u9069\u61c9\u75c7\u70baHPV16\u578b\u4e4b\u6301\u7e8c\u6027\u611f\u67d3\uff0c\u4e14\u63a1\u7528DNA\u75ab\u82d7\u52a0\u4e0a\u878d\u5408\u86cb\u767d(TA-CIN) \u4e26\u4ee5\u808c\u8089\u6ce8\u5c04\u7684\u65b9\u5f0f\u9032\u884c\u6cbb\u7642 (NCT 03911076)\uff0c\u904e\u53bb\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u986f\u793a\uff0c\u8ffd\u8e64\u81f312\u500b\u6708\u5f8c\uff0c11\u540d\u60a3\u8005\u4e2d\u67097\u540d\u9ad4\u5167HPV16\u578b\u75c5\u6bd2\u5b8c\u5168\u6e05\u9664\uff0c\u7d50\u679c\u5df2\u76f8\u7576\u4e0d\u932f\u3002\u4f46\u8003\u91cf\u4e0b\u4e00\u4ee3\u75ab\u82d7PVX-8\u6db5\u84cb\u7684\u75c5\u6bd2\u985e\u578b\u8f03\u5ee3\uff0c\u56e0\u6b64\u4f73\u63da\u9078\u64c7\u6295\u5165\u65b0\u4e00\u4ee3\u75ab\u82d7PVX-8\u7684\u958b\u767c\uff0c\u76ee\u524d\u65b0\u4e00\u4ee3\u85e5\u54c1\u53ca\u5b89\u6170\u5291\u5747\u4ee5\u751f\u7522\u5b8c\u7562\uff0c\u9810\u8a08\u65bc2024\u5e74\u958b\u5c55PVX-8\u7684\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\u3002[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;container&#8221;][vc_column][vc_sin 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