{"id":72087,"date":"2021-08-31T20:47:17","date_gmt":"2021-08-31T20:47:17","guid":{"rendered":"https:\/\/papivax.com\/?page_id=72087"},"modified":"2024-03-30T18:17:05","modified_gmt":"2024-03-30T18:17:05","slug":"our-technologies-expanded","status":"publish","type":"page","link":"https:\/\/papivax.com\/zh\/our-technologies\/our-technologies-expanded\/","title":{"rendered":"\u4f73\u63da\u751f\u6280\u7684\u6280\u8853"},"content":{"rendered":"

[vc_row type=”container” padding_top=”” padding_bottom=”” css=”.vc_custom_1458057033586{margin-bottom: 0px !important;}”][vc_column][vc_column_text]<\/p>\n

\u4f73\u63da\u64c1\u6709\u4e00\u7cfb\u5217\u7684\u6280\u8853\u5e73\u53f0\uff0c\u5728\u6838\u9178\u514d\u75ab\u7642\u6cd5\u7684\u5019\u9078\u85e5\u7269\u958b\u767c\u4e0a\uff0c\u6211\u5011\u6a6b\u5411\u6574\u5408\u5404\u9805\u5e73\u53f0\uff0c\u7814\u767c\u51fa\u6578\u7a2e\u5b89\u5168\u3001\u6709\u6548\u7684\u85e5\u54c1\uff0c\u4e26\u5728\u4eba\u9ad4\u81e8\u5e8a\u5be6\u9a57\u4e2d\u7372\u5f97\u826f\u597d\u7684\u9a57\u8b49\u3002\u4f73\u63da\u514d\u75ab\u7642\u6cd5\u5e73\u53f0\u6838\u5fc3\u6280\u8853\u5982\u4e0b\uff1a<\/h5>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”container” css=”.vc_custom_1462284973588{margin-bottom: 15px !important;}”][vc_column][vc_column_text][\/vc_column_text][vc_column_text](1) DNA\u8cea\u9ad4\u8f09\u9ad4\uff1a<\/strong><\/p>\n

DNA\u75ab\u82d7\u662f\u514d\u75ab\u7642\u6cd5\u7684\u7406\u60f3\u5e73\u53f0\uff0c\u6211\u5011\u7684\u6280\u8853\u4e0d\u50c5\u80fd\u5920\u8a98\u5c0e\u7279\u5b9a\u6297\u539f\u7684T\u7d30\u80de\u53cd\u61c9\uff0cDNA\u5291\u578b\u7684\u85e5\u54c1\u66f4\u517c\u5177\u88fd\u9020\u7c21\u55ae\u3001\u751f\u7522\u6210\u672c\u4f4e\u3001\u7a69\u5b9a\u6027\u9ad8\uff0c\u8207\u5176\u4ed6\u751f\u7269\u88fd\u5291\u76f8\u6bd4\u7121\u9700\u8907\u96dc\u7684\u914d\u65b9\u3002\u76f8\u8f03\u65bc\u9700\u8981\u4f50\u5291\u7684\u86cb\u767d\u8cea\u75ab\u82d7\uff0cDNA\u4e0d\u50c5\u751f\u7522\u6210\u672c\u4f4e\uff0c\u66f4\u5177\u6709\u512a\u79c0\u7684\u5b89\u5168\u6027\u3002\u5728\u7d04\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b78\u7684\u7814\u7a76\u4eba\u54e1\u901a\u904e\u5c0d\u5404\u7a2e\u6838\u9178\u8f09\u9ad4\u53ca\u878d\u5408\u86cb\u767d\u9032\u884c\u4e86\u5ee3\u6cdb\u7be9\u9078\uff0c\u78ba\u5b9a\u4e86\u80fd\u5920\u589e\u5f37\u514d\u75ab\u53cd\u61c9\uff08\u5c24\u5176\u662f\u5c0dHPV\u6297\u539f\u548c\u5176\u4ed6\u6297\u539f\u7684\u514d\u75ab\u53cd\u61c9\uff09\u7684\u5019\u9078\u5e73\u53f0\u3002\u5176\u4e2d\u6700\u6709\u524d\u666f\u7684\u5e73\u53f0\u70ba\u71b1\u4f11\u514b\u86cb\u767d\uff08heat shock proteins\uff0c\u7c21\u7a31 HSPs\uff09\uff0c\u5305\u62ec\u4f86\u81ea\u7d30\u83cc\uff08M.bovis\uff09\u7684HSP70\u53ca\u4eba\u985e\u9223\u7db2\u86cb\u767dCalreticulin (CRT)\uff0c\u76f8\u8f03\u65bc\u4f7f\u7528\u55ae\u7368\u6297\u539f\uff0c\u82e5\u4ee5\u71b1\u4f11\u514b\u86cb\u767d\u53ca\u9223\u7db2\u86cb\u767d(CRT)\u505a\u70ba\u4f34\u8b77\u86cb\u767d(Chaperone)\u5354\u52a9\u523a\u6fc0\u6a39\u7a81\u72c0\u7d30\u80de\u7684\u4ea4\u53c9\u5448\u905e\uff0c\u4f7f\u878d\u5408\u7684HPV \u6297\u539f\u5177\u6709\u9ad8\u5ea6\u514d\u75ab\u539f\u6027\uff0c\u53ef\u4f7f\u9ad4\u5167\u514d\u75ab\u53cd\u61c9\u63d0\u9ad850\u500d\u4ee5\u4e0a\u3002\u751f\u7269\u6a5f\u8f49\u8868\u660e\uff0cHSP70\u53ef\u8207\u76ee\u6a19\u6297\u539f\u878d\u5408\u4e26\u901a\u904e\u591a\u7a2e\u9014\u5f91\u986f\u8457\u589e\u5f37\u878d\u5408\u6297\u539f\u7279\u7570\u6027\u514d\u75ab\u53cd\u61c9\uff08\u898b\u57161\uff09\u3002\u7e3d\u9ad4\u800c\u8a00\uff0cHSP70\u901a\u904e\u4fc3\u9032\u6297\u539f\u9032\u5165\u6297\u539f\u5448\u73fe\u7d30\u80de\uff0c\u9032\u800c\u5448\u905e\u7d66\u514d\u75ab\u6548\u61c9\u7d30\u80de\uff0c\u53ef\u4ee5\u4fc3\u4f7f\u9ad4\u5167\u514d\u75ab\u7d30\u80de\u6e05\u9664\u53d7\u75c5\u6bd2\u611f\u67d3\u7684\u7d30\u80de\u3002HSP\u9664\u4e86\u4fc3\u9032\u6297\u539f\u7684\u8655\u7406\u548c\u5448\u905e\u5916\uff0c\u9084\u5145\u7576\u514d\u75ab\u7cfb\u7d71\u7684\u201c\u7d05\u65d7\u201d\uff0c\u4fc3\u4f7f\u514d\u75ab\u523a\u6fc0\u4fe1\u865f\u4e0a\u8abf\u3002\u4f73\u63daDNA\u6cbb\u7642\u6027\u75ab\u82d7\u7684\u6280\u8853\u70ba\u6e90\u81ea\u65bc\u7f8e\u570b\u7d04\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b78(Johns Hopkins University, JHU)\u7368\u5bb6\u6388\u6b0a\u7684 HPV DNA\u6cbb\u7642\u6027\u75ab\u82d7\u6280\u8853\uff0c\u8a72\u6280\u8853\u662f\u7531\u7d04\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b78\u7684\u5433\u5b50\u4e11\u535a\u58eb(\u4e2d\u7814\u9662\u9662\u58eb)\u53caRichard Roden\u535a\u58eb\u6240\u767c\u660e\u3002\u57fa\u65bc\u8a72\u8cea\u9ad4\u8f09\u9ad4\u6280\u8853\uff0c\u4f73\u63da\u5df2\u958b\u767c\u51fa\u4e00\u7cfb\u5217\u91dd\u5c0d\u9ad8\u5371\u96aa\u578bHPV\u75c5\u6bd2(HPV16\u3001HPV18\u578b)\u611f\u67d3\u5f15\u8d77\u4e4b\u76f8\u95dc\u9069\u61c9\u75c7\u7684DNA\u6cbb\u7642\u6027\u75ab\u82d7\uff0c\u4e26\u9678\u7e8c\u65bc\u5404\u9805\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5f97\u5230\u9a57\u8b49\u3002<\/p>\n

 <\/p>\n

\"\"<\/p>\n

\u5716 1:\u71b1\u4f11\u514b\u86cb\u767d(Heat Shock Proteins,HSPs)\u5c0d\u514d\u75ab\u523a\u6fc0\u793a\u610f\u5716<\/p>\n

[\/vc_column_text][vc_column_text]<\/p>\n

(2)\u00a0\u5f37\u5927\u7684 DNA\u8f09\u9ad4 \/ \u85e5\u7269\u905e\u9001\u6280\u8853\uff1a<\/h4>\n

TriGrid\u00ae Delivery System\u662f\u4e00\u7a2e\u6280\u8853\u4e0a\u512a\u8d8a\u3001\u4e14\u7d93\u904e\u81e8\u5e8a\u6e2c\u8a66\u7684\u96fb\u7a7f\u5b54\u6280\u8853\uff0c\u53ef\u4ee5\u986f\u8457\u63d0\u9ad8DNA\u751f\u7269\u88fd\u5291\u7684\u6548\u529b\u3002\u901a\u904e\u7ba1\u7406\u85e5\u7269\u548c\u96fb\u7a7f\u5b54\u61c9\u7528\u96c6\u6210\u5230\u55ae\u4e00\u7684\u81ea\u52d5\u5316\u8a2d\u5099\u4e2d\uff0cTriGrid\u00ae \u6280\u8853\u80fd\u5920\u4ee5\u7a69\u5b9a\u4e00\u81f4\u7684\u65b9\u5f0f\u9032\u884c\u85e5\u7269\u50b3\u905e\uff0c\u4e26\u652f\u6301\u5c0d\u65bc\u905e\u9001\u751f\u7269\u88fd\u5291\u7684\u5546\u696d\u5316\u3002
\n\u6b64\u7cfb\u7d71\u6700\u521d\u7531Ichor Medical Systems\u958b\u767c\uff0c\u800cPBI\u6536\u8cfc\u4e86TriGrid\u6280\u8853\uff0c\u7528\u65bc\u50b3\u905e\u57fa\u65bcDNA\u7684\u75ab\u82d7\u5019\u9078\u7269\uff0c\u5c08\u6ce8\u5728\u6cbb\u7642\u8207HPV\u76f8\u95dc\u7684\u75be\u75c5\u3002TriGrid \u00ae \u6280\u8853\u5df2\u88ab\u5b78\u8853\u754c\u548c\u5546\u696d\u958b\u767c\u8a8d\u540c\uff0c\u7528\u65bc\u50b3\u905e\u5176\u7279\u6709\u7684DNA\u75ab\u82d7\u3002\u8a72\u6280\u8853\u9084\u88ab\u5ee3\u6cdb\u8a55\u4f30\u7528\u65bc\u57fa\u65bcDNA\u7684\u75ab\u82d7\u6297\u9ad4\u50b3\u905e\u3002PBI\u4e5f\u7e7c\u7e8c\u5c0b\u6c42\u6230\u7565\u5408\u4f5c\u5925\u4f34\u95dc\u4fc2\uff0c\u70ba\u6709\u8208\u8da3\u64f4\u5c55\u5176\u57fa\u65bcDNA\u7684\u751f\u7269\u88fd\u5291\u7522\u54c1\u7ba1\u9053\u7684\u5408\u4f5c\u5925\u4f34\uff0c\u63d0\u4f9bTriGrid\u00ae \u6280\u8853\u3002<\/p>\n

TriGrid \u00ae\u905e\u9001\u7cfb\u7d71\u662f\u4e00\u7a2e\u7528\u65bc\u589e\u5f37\u6838\u9178\u5728\u9aa8\u9abc\u808c\u7d30\u80de\u5167\u50b3\u905e\u7684\u81e8\u5e8a\u88dd\u7f6e\u3002
\n\u8a72\u7cfb\u7d71\u7531\u4e09\u500b\u4e3b\u8981\u7d44\u4ef6\u7d44\u6210\uff08\u898b\u57162\uff09\u3002<\/p>\n

    \n
  • \u8108\u885d\u523a\u6fc0\u5668<\/strong>\u63a7\u5236\u8457\u7ba1\u7406\u4ecb\u9762\u4e26\u7522\u751f\u96fb\u7a7f\u5b54\u8108\u885d\u3002<\/li>\n
  • \u96c6\u6210\u5f0f\u61c9\u7528\u5668<\/strong>\u662f\u4e00\u7a2e\u53ef\u91cd\u8907\u4f7f\u7528\u7684\u624b\u6301\u88dd\u7f6e\uff0c\u5176\u4e2d\u8a2d\u6709\u4e00\u6b21\u6027\u4f7f\u7528\u7684\u5361\u5323\u3002\u5b83\u53ef\u4ee5\u5728\u55ae\u500b\u6309\u9215\u6309\u58d3\u4e0b\u81ea\u52d5\u5c55\u958b\u96fb\u6975\uff0c\u4e26\u958b\u59cb\u5c0d\u751f\u7269\u88fd\u5291\u9032\u884c\u7ba1\u7406\u3002\u5176\u81ea\u52d5\u5316\u8a2d\u8a08\u63d0\u4f9b\u4e86\u4e00\u500b\u53ef\u91cd\u8907\u7684\u61c9\u7528\u7a0b\u5e8f\u7a0b\u5e8f\uff0c\u4e14\u9700\u8981\u6700\u4f4e\u7a0b\u5ea6\u7684\u64cd\u4f5c\u57f9\u8a13\u3002<\/li>\n
  • \u61c9\u7528\u5361\u5323<\/strong>\u662f\u4e00\u500b\u7121\u83cc\u7684\u4e00\u6b21\u6027\u7d44\u4ef6\uff0c\u5176\u4e2d\u5305\u542b\u6838\u9178\u8a66\u5291\u7684\u7ba1\u7406\u4ee5\u53ca\u96fb\u7a7f\u5b54\u7a0b\u5e8f\u7684TriGrid \u00ae\u96fb\u6975\u9663\u5217\u3002<\/li>\n<\/ul>\n

    \"\"<\/p>\n

    \u57162. TriGrid \u85e5\u7269\u905e\u9001\u7cfb\u7d71<\/p>\n

     <\/p>\n

    TriGrid\u00ae \u6280\u8853\u70ba\u5169\u500b\u5ee3\u6cdb\u985e\u5225\u7684\u6838\u9178\u5019\u9078\u7269\u63d0\u4f9b\u4e86\u50b3\u905e\u89e3\u6c7a\u65b9\u6848:<\/p>\n

    1. \u6838\u9178\u75ab\u82d7\/\u514d\u75ab\u6cbb\u7642<\/strong><\/p>\n

      \n
    • \u50b3\u7d71\u75ab\u82d7\u65b9\u6cd5\u7684\u66ff\u4ee3\u54c1\n
        \n
      • \u9810\u9632\u50b3\u67d3\u6027\u75be\u75c5<\/li>\n<\/ul>\n<\/li>\n
      • \u514d\u75ab\u6cbb\u7642\/\u65b0\u578b\u75ab\u82d7\u9069\u61c9\u75c7\n
          \n
        • \u816b\u7624\u5b78<\/li>\n
        • \u6162\u6027\u75c5\u6bd2\u611f\u67d3<\/li>\n
        • \u81ea\u9ad4\u514d\u75ab\u75be\u75c5\/\u904e\u654f<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

          2. \u86cb\u767d\u8cea\/\u55ae\u514b\u9686\u6297\u9ad4 (mAb) \u50b3\u905e<\/strong><\/p>\n

            \n
          • \u91cd\u7d44\u7269\u8cea\u7684\u7cfb\u7d71\u50b3\u905e\u66ff\u4ee3\u54c1\n
              \n
            • \u5df2\u6279\u51c6\u548c\/\u6216\u65b0\u578b\u85e5\u7269<\/li>\n
            • \u4f4e\u6210\u672c\u6301\u7e8c\u88ab\u52d5\u514d\u75ab\uff08mAb\uff09<\/li>\n<\/ul>\n<\/li>\n
            • \u5c40\u90e8\u86cb\u767d\u8cea\u8868\u9054\n
                \n
              • \u4fc3\u9032\u91cd\u8840\u7ba1\u5316\/\u50b7\u53e3\u7652\u5408\u7684\u751f\u9577\u56e0\u5b50<\/li>\n
              • \u514d\u75ab\u8abf\u7bc0\u5291<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                [\/vc_column_text][vc_column_text]<\/p>\n

                (3)\u00a0\u91cd\u7d44\u75d8\u86cb\u767d\u75ab\u82d7\u8f09\u9ad4\uff1a<\/h4>\n

                \u5118\u7ba1\u4f73\u63da\u6240\u7814\u767c\u7684DNA\u75ab\u82d7\u5df2\u5728\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u4e0a\u986f\u793a\u51fa\u5177\u6709\u76f8\u7576\u512a\u79c0\u7684\u8a98\u767cT\u7d30\u80de\u53cd\u61c9\u53ca\u75c5\u6bd2\u6e05\u9664\u80fd\u529b\uff0c\u4f46\u5728\u665a\u671f\u7684\u764c\u75c7\u6216\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u60a3\u8005\u4e2d\uff0c\u5982\u4f55\u80fd\u9032\u4e00\u6b65\u63d0\u9ad8\u514d\u75ab\u53cd\u61c9\u4ee5\u9054\u5230\u9810\u671f\u7684\u7642\u6548\uff0c\u662f\u7814\u767c\u904e\u7a0b\u4e2d\u5fc5\u7136\u6703\u78b0\u5230\u7684\u554f\u984c\u3002\u904e\u53bb\u6578\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u76f8\u8f03\u65bc\u55ae\u4e00\u6297\u539f\uff0c\u82e5\u63a1\u7528DNA\u75ab\u82d7\u642d\u914d\u75d8\u75c5\u6bd2\u86cb\u767d\u7684\u7d44\u5408\u6cbb\u7642\uff0c\u53ef\u4ee5\u986f\u8457\u63d0\u9ad8\u60a3\u8005\u7684\u514d\u75ab\u53cd\u61c9\u3002\u4f73\u63da\u57fa\u65bcDNA\u514d\u75ab\u5e73\u53f0\u7684\u672a\u4f86\u767c\u5c55\u6027\uff0c\u5411\u82f1\u570b\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3(Cancer Research UK)\u8cfc\u5165\u76f8\u95dc\u91cd\u7d44\u75d8\u86cb\u767d\u75ab\u82d7(TA-HPV)\u4e4b\u6280\u8853\u53ca\u5c08\u5229\uff0c\u4f5c\u70ba\u514d\u75ab\u7642\u6cd5\u4e2d\u7684\u300c\u52a0\u514d\u300d\u75ab\u82d7\uff0c\u9032\u4e00\u6b65\u63d0\u9ad8\u4f73\u63da\u4e0b\u4e00\u4ee3\u7522\u54c1\u7684\u7642\u6548(\u8a73\u898b\u5716\u4e94)\u3002\u5176\u4e2dTA-HPV \u7684\u75d8\u75c5\u6bd2\u8f09\u9ad4\uff0c\u9664\u4e86\u5177\u6709\u7d30\u80de\u5167\u53ef\u8907\u88fd\u3001\u53ef\u65bc\u9ad4\u5167\u5145\u5206\u8868\u9054\u6297\u539f\u7684\u7279\u6027\u5916\uff0c\u904e\u53bb\u5df2\u666e\u904d\u4f7f\u7528\u5728\u5929\u82b1\u75ab\u82d7\uff0c\u6545\u65bc\u81e8\u5e8a\u4f7f\u7528\u4e0a\u5b89\u5168\u6027\u7121\u865e\uff0c\u4e14\u4f73\u63da\u5df2\u53d6\u5f97\u63a5\u7a2e\u7642\u7a0b\u76f8\u95dc\u7684\u5c08\u5229 (US10512683)\u3002<\/p>\n

                 <\/p>\n

                \"\"<\/p>\n

                \u57163: PVX7 \u521d\u514d-\u52a0\u5f37\u514d\u75ab\u6cbb\u7642\u65b9\u6848\u793a\u610f\u5716<\/p>\n

                [\/vc_column_text][vc_column_text]<\/p>\n

                (4)\u00a0\u5168\u8eab\u6027\u7684\u514d\u75ab\u8abf\u7bc0\u5291\uff1a<\/h4>\n

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